MOLECULAR DOCKING AND MOUSE MODELING SUGGEST CMKLR1 AND INSR AS TARGETS FOR IMPROVING PCOS PHENOTYPES BY MINOCYCLINE

Polycystic ovary syndrome (PCOS) is the most common cause of women’s infertility.Some inflammatory pathways play a pivotal role in the pathogenesis of PCOS.This study aimed to investigate the possible beneficial effects of minocycline on chemokine-like receptor 1 (CMKLR1) and Insulin Receptor (INSR) in a PCOS model.A molecular docking study was i

Lamin family proteins are structural components of a filamentous framework, the nuclear lamina (NL), underlying the inner membrane of nuclear envelope.The NL not only plays a role in nucleus mechanical support and nuclear shaping, but Hoodie is also involved in many cellular processes including DNA replication, gene expression and chromatin positio